CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C05861
Pert ID:	BRD-K44084986
Compound Name:	Y-27632
Targets:	PKIA\|PKN2\|PRKACA\|PRKCE\|ROCK1\|ROCK2
MoA:	rho associated kinase inhibitor
SMILES:	C[C@@H](N)[C@H]1CC[C@@H](CC1)C(=O)Nc1ccncc1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
6756	BRD-K44084986	A375	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
7157	BRD-K44084986	A549	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
7324	BRD-K44084986	HA1E	10 uM	24 h	0.29	1.22	0.48	0.0	0.0	0.0
7661	BRD-K44084986	HCC515	10 uM	6 h	0.0	0.0	0.0	0.27	0.96	0.34
7868	BRD-K44084986	HT29	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
8282	BRD-K44084986	MCF??7.00	10 uM	6 h	0.26	1.09	0.22	0.29	1.02	0.47
8680	BRD-K44084986	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
96919	BRD-K44084986	PC3	10 uM	24 h	-0.21	-0.85	0.01	0.0	0.0	0.0
99547	BRD-K44084986	U2OS	20 uM	6 h	0.26	1.1	0.24	0.0	0.0	0.0

Summary