CMap Candidate Details
Structure:
| CMap ID: | C05865 |
| Pert ID: | BRD-K60476892 |
| Compound Name: | YC-1 |
| Targets: | GUCY1A2|GUCY1A3|GUCY1B3|HIF1A |
| MoA: | guanylyl cyclase activator |
| SMILES: | OCc1ccc(o1)-c1nn(Cc2ccccc2)c2ccccc12 |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 2911 | BRD-K60476892 | HA1E | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 3243 | BRD-K60476892 | HCC515 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.28 | -0.95 | 0.41 |
| 3531 | BRD-K60476892 | PC3 | 10 uM | 24 h | 0.3 | 1.26 | 0.58 | 0.0 | 0.0 | 0.0 |
| 3843 | BRD-K60476892 | VCAP | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 41803 | BRD-K60476892 | A375 | 10 uM | 6 h | -0.28 | -1.15 | 0.44 | 0.0 | 0.0 | 0.0 |
| 41957 | BRD-K60476892 | A549 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 42411 | BRD-K60476892 | ASC | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.2 | 0.72 | 0.02 |
| 42728 | BRD-K60476892 | HEPG2 | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 43029 | BRD-K60476892 | HT29 | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.35 | 1.25 | 1.29 |
| 43336 | BRD-K60476892 | MCF??7.00 | 10 uM | 6 h | 0.16 | 0.67 | 0.0 | 0.0 | 0.0 | 0.0 |
| 43592 | BRD-K60476892 | NPC | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.3 | 1.05 | 0.56 |
| 44152 | BRD-K60476892 | SKB | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 53598 | BRD-K60476892 | HUH7 | 4 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.24 | 0.87 | 0.17 |
| 53680 | BRD-K60476892 | PHH | 15 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.26 | 0.91 | 0.24 |
| 99714 | BRD-K60476892 | U2OS | 15 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |