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CMap Candidate Details

Structure:
CMap ID: C05868
Pert ID: BRD-K76703230
Compound Name: YM-155
Targets: BIRC5
MoA: survivin inhibitor
SMILES: COCCn1c2c(C(=O)c3ccccc3C2=O)[n+](Cc2cnccn2)c1C
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
8983 BRD-K76703230 A375 0.3 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
9231 BRD-K76703230 A549 0.3 uM 6 h -0.17 -0.71 0.0 0.0 0.0 0.0
9505 BRD-K76703230 AGS 0.3 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9809 BRD-K76703230 H1299 0.3 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10314 BRD-K76703230 HCC515 0.3 uM 6 h 0.0 0.0 0.0 -0.44 -1.49 15.35
10592 BRD-K76703230 HCT116 0.3 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11297 BRD-K76703230 MCF??7.00 0.3 uM 6 h -0.25 -1.03 0.2 0.0 0.0 0.0
11573 BRD-K76703230 NCIH2073 0.3 uM 6 h 0.0 0.0 0.0 -0.42 -1.41 2.02
11836 BRD-K76703230 NCIH508 0.3 uM 6 h 0.19 0.79 0.0 0.0 0.0 0.0
12128 BRD-K76703230 NCIH596 0.3 uM 6 h 0.0 0.0 0.0 -0.52 -1.76 15.65
12379 BRD-K76703230 NOMO1 0.3 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12866 BRD-K76703230 SW480 0.3 uM 6 h 0.0 0.0 0.0 -0.48 -1.62 15.65
13357 BRD-K76703230 U937 0.3 uM 6 h 0.24 1.02 0.12 0.42 1.5 2.27
13678 BRD-K76703230 VCAP 0.3 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
116457 BRD-K76703230 HEPG2 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121766 BRD-K76703230 HELA 0.125 uM 24 h 0.0 0.0 0.0 -0.31 -1.03 0.64
121870 BRD-K76703230 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129794 BRD-K76703230 HA1E 0.01 uM 24 h 0.2 0.85 0.0 -0.31 -1.06 0.72
129831 BRD-K76703230 HEK293 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129895 BRD-K76703230 HT29 0.08 uM 24 h 0.0 0.0 0.0 -0.31 -1.04 0.68
129957 BRD-K76703230 MCF10A 0.03 uM 24 h 0.25 1.03 0.13 0.0 0.0 0.0
130042 BRD-K76703230 MDAMB231 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130083 BRD-K76703230 PC3 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130114 BRD-K76703230 THP1 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).