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CMap Candidate Details

Structure:
CMap ID: C05876
Pert ID: BRD-K12932420
Compound Name: YM-976
Targets: PDE4A
MoA: phosphodiesterase inhibitor
SMILES: CCc1ccc2c(nc(=O)n(CC)c2n1)-c1cccc(Cl)c1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4548 BRD-K12932420 HCC515 10 uM 6 h 0.0 0.0 0.0 -0.4 -1.35 1.88
4895 BRD-K12932420 VCAP 10 uM 24 h 0.0 0.0 0.0 0.27 0.97 0.34
44674 BRD-K12932420 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
44860 BRD-K12932420 ASC 10 uM 24 h -0.31 -1.28 0.77 0.0 0.0 0.0
45165 BRD-K12932420 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.31 1.08 0.66
45975 BRD-K12932420 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
46295 BRD-K12932420 PHH 10 uM 24 h 0.0 0.0 0.0 -0.24 -0.81 0.13
46610 BRD-K12932420 SKB 10 uM 24 h -0.25 -1.04 0.21 -0.33 -1.11 0.9
122243 BRD-K12932420 A375 3.33 uM 24 h 0.0 0.0 0.0 0.31 1.1 0.69
122354 BRD-K12932420 MCF10A 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122410 BRD-K12932420 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.31 1.08 0.66
122465 BRD-K12932420 THP1 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130584 BRD-K12932420 HA1E 2.22 uM 24 h 0.0 0.0 0.0 -0.28 -0.93 0.35
130617 BRD-K12932420 HEK293 2.22 uM 24 h 0.22 0.9 0.02 0.0 0.0 0.0
130658 BRD-K12932420 HELA 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130700 BRD-K12932420 HT29 0.08 uM 24 h 0.0 0.0 0.0 -0.35 -1.19 1.15
130758 BRD-K12932420 MCF??7.00 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130809 BRD-K12932420 PC3 0.74 uM 24 h 0.0 0.0 0.0 0.29 1.02 0.49
130828 BRD-K12932420 YAPC 0.01 uM 24 h 0.0 0.0 0.0 -0.2 -0.69 0.02
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).