CMap Candidate Details
Structure:
| CMap ID: | C05895 |
| Pert ID: | BRD-K16542329 |
| Compound Name: | zaprinast |
| Targets: | GPR35|PDE1A|PDE4D|PDE5A|PDE9A |
| MoA: | phosphodiesterase inhibitor |
| SMILES: | CCCOc1ccccc1-c1nc2[nH]nnc2c(=O)[nH]1 |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 51279 | BRD-K16542329 | MCF??7.00 | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 91406 | BRD-K16542329 | HUH7 | 12.5 uM | 72 h | -0.31 | -1.28 | 0.77 | 0.0 | 0.0 | 0.0 |
| 96779 | BRD-K16542329 | PC3 | 10 uM | 24 h | 0.23 | 0.96 | 0.07 | 0.0 | 0.0 | 0.0 |
| 100148 | BRD-K16542329 | U2OS | 20 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 120239 | BRD-K16542329 | A375 | 10 uM | 24 h | -0.22 | -0.92 | 0.06 | 0.0 | 0.0 | 0.0 |
| 120275 | BRD-K16542329 | A549 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.34 | -1.15 | 1.05 |
| 120312 | BRD-K16542329 | HA1E | 1.11 uM | 24 h | 0.16 | 0.68 | 0.0 | 0.0 | 0.0 | 0.0 |
| 120359 | BRD-K16542329 | HELA | 1.11 uM | 3 h | 0.0 | 0.0 | 0.0 | -0.24 | -0.8 | 0.12 |
| 120470 | BRD-K16542329 | YAPC | 0.37 uM | 24 h | 0.26 | 1.07 | 0.2 | 0.25 | 0.9 | 0.21 |
| 128947 | BRD-K16542329 | HT29 | 2.22 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |