CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C05905
Pert ID:	BRD-K31553034
Compound Name:	zibotentan
Targets:	EDNRA
MoA:	endothelin receptor antagonist
SMILES:	COc1nc(C)cnc1NS(=O)(=O)c1cccnc1-c1ccc(cc1)-c1nnco1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
29828	BRD-K31553034	A375	10 uM	6 h	-0.27	-1.14	0.42	0.0	0.0	0.0
30418	BRD-K31553034	ASC	10 uM	24 h	0.0	0.0	0.0	-0.31	-1.03	0.65
30726	BRD-K31553034	HA1E	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
31017	BRD-K31553034	HCC515	10 uM	6 h	0.0	0.0	0.0	-0.35	-1.18	1.14
31322	BRD-K31553034	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
31653	BRD-K31553034	HT29	10 uM	6 h	0.0	0.0	0.0	-0.3	-1.01	0.55
31859	BRD-K31553034	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
32165	BRD-K31553034	NEU	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
32402	BRD-K31553034	NPC	10 uM	24 h	0.0	0.0	0.0	-0.31	-1.04	0.65
32627	BRD-K31553034	PC3	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
33001	BRD-K31553034	SKB	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
33273	BRD-K31553034	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
96131	BRD-K31553034	A549	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary