CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C05907
Pert ID:	BRD-A56359832
Compound Name:	zileuton
Targets:	ALOX5
MoA:	leukotriene synthesis inhibitor; lipoxygenase inhibitor
SMILES:	CC(N(O)C(N)=O)c1cc2ccccc2s1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
9597	BRD-A56359832	H1299	150 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
10188	BRD-A56359832	HCC515	150 uM	24 h	0.0	0.0	0.0	0.24	0.84	0.12
10405	BRD-A56359832	HCT116	150 uM	6 h	0.0	0.0	0.0	-0.25	-0.84	0.18
10672	BRD-A56359832	HEPG2	150 uM	6 h	0.0	0.0	0.0	-0.22	-0.76	0.07
11658	BRD-A56359832	NCIH508	150 uM	6 h	0.0	0.0	0.0	-0.37	-1.23	1.28
11919	BRD-A56359832	NCIH596	150 uM	6 h	0.0	0.0	0.0	-0.21	-0.71	0.03
13153	BRD-A56359832	U937	150 uM	6 h	0.22	0.91	0.04	-0.39	-1.31	1.7
24536	BRD-A56359832	A549	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
24990	BRD-A56359832	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
25300	BRD-A56359832	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
91074	BRD-A56359832	HUH7	15 uM	72 h	0.0	0.0	0.0	0.0	0.0	0.0
121574	BRD-A56359832	A375	10 uM	24 h	0.0	0.0	0.0	0.26	0.91	0.23
121620	BRD-A56359832	HA1E	3.33 uM	24 h	-0.19	-0.79	0.0	0.36	1.28	1.37
121651	BRD-A56359832	HELA	0.04 uM	24 h	0.21	0.88	0.02	0.24	0.85	0.14
121667	BRD-A56359832	HT29	0.125 uM	24 h	0.0	0.0	0.0	-0.34	-1.15	1.06
121714	BRD-A56359832	YAPC	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
129706	BRD-A56359832	PC3	0.08 uM	24 h	-0.3	-1.24	0.64	-0.25	-0.85	0.19

Summary