CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C05913
Pert ID:	BRD-K05151076
Compound Name:	ZK-164015
Targets:	ESR1\|ESR2
MoA:	estrogen receptor antagonist
SMILES:	CCCCCS(=O)(=O)CCCCCCCCCCn1c(c(C)c2cc(O)ccc12)-c1ccc(O)cc1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
1727	BRD-K05151076	HA1E	10 uM	6 h	0.0	0.0	0.0	-0.31	-1.04	0.65
1869	BRD-K05151076	HCC515	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
2260	BRD-K05151076	PC3	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
2591	BRD-K05151076	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
41707	BRD-K05151076	A375	10 uM	6 h	0.0	0.0	0.0	0.27	0.95	0.31
41901	BRD-K05151076	A549	10 uM	24 h	0.0	0.0	0.0	-0.45	-1.52	15.35
42267	BRD-K05151076	ASC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
42603	BRD-K05151076	HEPG2	10 uM	6 h	-0.23	-0.96	0.1	-0.38	-1.28	1.45
42907	BRD-K05151076	HT29	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
43150	BRD-K05151076	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
43462	BRD-K05151076	NPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
43769	BRD-K05151076	PHH	10 uM	24 h	0.26	1.08	0.22	0.0	0.0	0.0
44048	BRD-K05151076	SKB	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
99991	BRD-K05151076	U2OS	10 uM	6 h	0.24	1.01	0.12	0.27	0.96	0.33

Summary