CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C05922
Pert ID:	BRD-K41337261
Compound Name:	ZM-306416
Targets:	EGFR\|FLT1\|FLT4\|KDR
MoA:	Abl kinase inhibitor; src inhibitor; VEGFR inhibitor
SMILES:	COc1cc2ncnc(Nc3ccc(Cl)cc3F)c2cc1OC
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
2881	BRD-K41337261	HA1E	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
3201	BRD-K41337261	HCC515	10 uM	24 h	0.22	0.91	0.04	0.4	1.41	2.19
3504	BRD-K41337261	PC3	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
3797	BRD-K41337261	VCAP	10 uM	24 h	0.21	0.89	0.02	0.0	0.0	0.0
39137	BRD-K41337261	A375	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
39327	BRD-K41337261	A549	10 uM	24 h	0.0	0.0	0.0	0.33	1.15	0.9
39699	BRD-K41337261	ASC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
40007	BRD-K41337261	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
40278	BRD-K41337261	HT29	10 uM	6 h	0.18	0.77	0.0	0.31	1.09	0.67
40473	BRD-K41337261	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	-0.38	-1.28	1.45
40815	BRD-K41337261	NEU	10 uM	24 h	-0.27	-1.1	0.36	0.0	0.0	0.0
41119	BRD-K41337261	NPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
41454	BRD-K41337261	SKB	10 uM	24 h	-0.2	-0.84	0.01	-0.21	-0.71	0.04
99515	BRD-K41337261	U2OS	10 uM	6 h	0.24	0.99	0.1	0.0	0.0	0.0

Summary