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CMap Candidate Details

Structure:
CMap ID: C05970
Pert ID: BRD-K68552125
Compound Name: 12-O-tetradecanoylphorbol-13-acetate
Targets: KCNT2|TRPV4
MoA: PKC activator
SMILES: CCCCCCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@]2(O)[C@@H]3C=C(C)C(=O)[C@@]3(O)CC(CO)=C[C@H]2[C@@H]2C(C)(C)[C@]12OC(C)=O
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1014 BRD-K68552125 CD34 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
1025 BRD-K68552125 HL60 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
1101 BRD-K68552125 U937 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
53409 BRD-K68552125 HEPG2 2.5 uM 24 h 0.0 0.0 0.0 -0.34 -1.13 1.0
53605 BRD-K68552125 HUH7 10 uM 6 h 0.0 0.0 0.0 -0.4 -1.34 1.85
53744 BRD-K68552125 PHH 10 uM 6 h 0.0 0.0 0.0 -0.35 -1.17 1.12
99389 BRD-K68552125 U2OS 8 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
126371 BRD-K68552125 A549 0.12 uM 24 h 0.0 0.0 0.0 -0.42 -1.41 2.02
126396 BRD-K68552125 HA1E 0.12 uM 24 h 0.0 0.0 0.0 -0.41 -1.38 2.02
126421 BRD-K68552125 HEK293 0.12 uM 24 h 0.17 0.7 0.0 0.0 0.0 0.0
126467 BRD-K68552125 HELA 0.12 uM 24 h 0.0 0.0 0.0 -0.54 -1.81 15.65
126531 BRD-K68552125 MCF??7.00 8 uM 24 h 0.18 0.76 0.0 0.0 0.0 0.0
126570 BRD-K68552125 PC3 0.12 uM 24 h 0.0 0.0 0.0 -0.37 -1.24 1.31
134339 BRD-K68552125 A375 0.07 uM 24 h 0.0 0.0 0.0 -0.43 -1.44 15.35
134451 BRD-K68552125 HT29 0.66 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134488 BRD-K68552125 HUVEC 0.025 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134532 BRD-K68552125 MCF10A 0.66 uM 24 h -0.24 -0.99 0.13 0.0 0.0 0.0
134588 BRD-K68552125 MDAMB231 0.006 uM 24 h 0.0 0.0 0.0 -0.31 -1.05 0.7
134645 BRD-K68552125 YAPC 0.025 uM 24 h 0.0 0.0 0.0 -0.34 -1.13 0.98
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).