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CMap Candidate Details

Structure:
CMap ID: C00599
Pert ID: BRD-K31928526
Compound Name: barasertib
Targets: AURKA|AURKB
MoA: Aurora kinase inhibitor
SMILES: CCN(CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)[nH]n3)ncnc2c1)CCOP(O)(O)=O
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
96974 BRD-K31928526 A375 3.33 uM 24 h 0.3 1.24 0.53 0.0 0.0 0.0
121731 BRD-K31928526 HA1E 0.125 uM 24 h 0.0 0.0 0.0 -0.25 -0.85 0.19
121785 BRD-K31928526 HT29 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121835 BRD-K31928526 PC3 3.33 uM 24 h 0.0 0.0 0.0 -0.27 -0.9 0.27
129814 BRD-K31928526 HEK293 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129866 BRD-K31928526 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129941 BRD-K31928526 MCF10A 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129990 BRD-K31928526 MCF??7.00 2.22 uM 24 h 0.2 0.85 0.01 -0.31 -1.03 0.63
130025 BRD-K31928526 MDAMB231 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130097 BRD-K31928526 THP1 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130148 BRD-K31928526 YAPC 0.08 uM 24 h 0.0 0.0 0.0 -0.3 -1.02 0.6
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).