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CMap Candidate Details

Structure:
CMap ID: C00600
Pert ID: BRD-K63923597
Compound Name: barasertib-HQPA
Targets: AURKB
MoA: Aurora kinase inhibitor
SMILES: CCN(CCO)CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)[nH]n3)ncnc2c1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
45 BRD-K63923597 BJAB 10 uM 4 h 0.24 0.99 0.09 0.0 0.0 0.0
110 BRD-K63923597 HBL1 0.125 uM 4 h 0.0 0.0 0.0 0.0 0.0 0.0
146 BRD-K63923597 K562 10 uM 4 h 0.0 0.0 0.0 -0.3 -1.0 0.52
167 BRD-K63923597 KMS34 0.66 uM 24 h -0.2 -0.82 0.0 0.0 0.0 0.0
209 BRD-K63923597 NALM6 2.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
248 BRD-K63923597 OCILY10 10 uM 24 h 0.0 0.0 0.0 -0.19 -0.65 0.01
281 BRD-K63923597 OCILY19 0.01 uM 24 h 0.0 0.0 0.0 -0.22 -0.73 0.05
325 BRD-K63923597 OCILY3 0.01 uM 24 h 0.0 0.0 0.0 0.28 0.98 0.37
365 BRD-K63923597 SKMEL5 2.5 uM 24 h 0.28 1.15 0.32 0.0 0.0 0.0
400 BRD-K63923597 THP1 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
458 BRD-K63923597 TMD8 10 uM 4 h 0.3 1.26 0.57 0.0 0.0 0.0
1243 BRD-K63923597 A549 1.11 uM 48 h 0.0 0.0 0.0 0.0 0.0 0.0
1347 BRD-K63923597 U2OS 1.11 uM 48 h 0.0 0.0 0.0 0.0 0.0 0.0
32212 BRD-K63923597 NEU 10 uM 24 h 0.29 1.2 0.42 0.0 0.0 0.0
32488 BRD-K63923597 NPC 10 uM 24 h 0.0 0.0 0.0 -0.26 -0.86 0.22
33487 BRD-K63923597 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34143 BRD-K63923597 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36305 BRD-K63923597 PHH 10 uM 24 h 0.0 0.0 0.0 0.28 0.99 0.4
36603 BRD-K63923597 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91518 BRD-K63923597 BT20 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91659 BRD-K63923597 MCF??7.00 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91756 BRD-K63923597 SKBR3 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92056 BRD-K63923597 HA1E 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92156 BRD-K63923597 HS578T 0.37 uM 3 h 0.0 0.0 0.0 -0.25 -0.84 0.17
92179 BRD-K63923597 HT29 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92208 BRD-K63923597 MCF10A 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92284 BRD-K63923597 MDAMB231 0.04 uM 24 h -0.25 -1.06 0.25 0.0 0.0 0.0
96881 BRD-K63923597 A375 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
96957 BRD-K63923597 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119272 BRD-K63923597 HCC515 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119301 BRD-K63923597 HEPG2 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).