CMap Candidate Details
Structure:
| CMap ID: | C06008 |
| Pert ID: | BRD-K44408410 |
| Compound Name: | 2-methoxyestradiol |
| Targets: | COMT|CYP19A1|CYP1A1|CYP1B1|HIF1A|TUBB |
| MoA: | hypoxia inducible factor inhibitor |
| SMILES: | COc1cc2[C@H]3CC[C@]4(C)[C@@H](O)CC[C@H]4[C@@H]3CCc2cc1O |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 90839 | BRD-K44408410 | MCF10A | 3.33 uM | 24 h | 0.14 | 0.59 | 0.0 | -0.36 | -1.2 | 1.21 |
| 121549 | BRD-K44408410 | A375 | 3.33 uM | 24 h | 0.24 | 0.98 | 0.09 | 0.0 | 0.0 | 0.0 |
| 121584 | BRD-K44408410 | HA1E | 10 uM | 24 h | -0.19 | -0.79 | 0.0 | -0.32 | -1.07 | 0.75 |
| 129594 | BRD-K44408410 | HELA | 0.74 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.27 | -0.9 | 0.28 |
| 129624 | BRD-K44408410 | HT29 | 0.74 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 129653 | BRD-K44408410 | MCF??7.00 | 2.22 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 129677 | BRD-K44408410 | PC3 | 2.22 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.34 | -1.15 | 1.07 |
| 129716 | BRD-K44408410 | YAPC | 2.22 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |