CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C06024
Pert ID:	BRD-K37846922
Compound Name:	3,3'-diindolylmethane
Targets:	AR\|HIF1A\|IFNG\|PI3
MoA:	CHK inhibitor; cytochrome P450 activator; indoleamine 2,3-dioxygenase inhibitor
SMILES:	C(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
34611	BRD-K37846922	HCC515	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
34878	BRD-K37846922	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
35316	BRD-K37846922	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	-0.37	-1.24	1.3
36554	BRD-K37846922	SKB	10 uM	24 h	-0.27	-1.14	0.43	-0.31	-1.05	0.72
36818	BRD-K37846922	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
44947	BRD-K37846922	ASC	10 uM	24 h	0.0	0.0	0.0	-0.29	-0.96	0.44
46380	BRD-K37846922	PHH	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
53310	BRD-K37846922	MCF10A	30 uM	24 h	0.0	0.0	0.0	-0.37	-1.26	1.35
98893	BRD-K37846922	NEU	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
99145	BRD-K37846922	NPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
123226	BRD-K37846922	A375	1.11 uM	24 h	0.0	0.0	0.0	0.23	0.8	0.08
123392	BRD-K37846922	MDAMB231	1.11 uM	24 h	0.0	0.0	0.0	-0.3	-1.0	0.54
123414	BRD-K37846922	PC3	1.11 uM	24 h	0.27	1.12	0.26	-0.27	-0.91	0.31
131539	BRD-K37846922	A549	0.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131576	BRD-K37846922	HA1E	0.22 uM	24 h	-0.28	-1.16	0.48	0.0	0.0	0.0
131615	BRD-K37846922	HEK293	0.22 uM	24 h	-0.22	-0.91	0.05	-0.33	-1.11	0.92
131650	BRD-K37846922	HELA	0.001 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131679	BRD-K37846922	HT29	0.003 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131708	BRD-K37846922	HUVEC	0.22 uM	24 h	-0.24	-0.99	0.13	-0.3	-1.01	0.57
131761	BRD-K37846922	JURKAT	0.08 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131926	BRD-K37846922	THP1	0.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131947	BRD-K37846922	YAPC	0.001 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary