Logo 1 Logo 2

CMap Candidate Details

Structure:
CMap ID: C00604
Pert ID: BRD-K53581288
Compound Name: baricitinib
Targets: JAK1|JAK2
MoA: JAK inhibitor
SMILES: CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
48 BRD-K53581288 BJAB 10 uM 4 h 0.0 0.0 0.0 0.0 0.0 0.0
112 BRD-K53581288 HBL1 10 uM 4 h 0.0 0.0 0.0 0.0 0.0 0.0
149 BRD-K53581288 K562 10 uM 4 h 0.0 0.0 0.0 -0.38 -1.29 1.53
170 BRD-K53581288 KMS34 0.66 uM 24 h 0.0 0.0 0.0 -0.21 -0.7 0.03
212 BRD-K53581288 NALM6 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
251 BRD-K53581288 OCILY10 2.5 uM 24 h -0.24 -0.99 0.14 0.0 0.0 0.0
308 BRD-K53581288 OCILY19 10 uM 4 h 0.0 0.0 0.0 0.0 0.0 0.0
328 BRD-K53581288 OCILY3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
368 BRD-K53581288 SKMEL5 0.01 uM 24 h -0.23 -0.95 0.09 0.0 0.0 0.0
418 BRD-K53581288 THP1 10 uM 4 h 0.0 0.0 0.0 0.22 0.8 0.08
438 BRD-K53581288 TMD8 10 uM 24 h 0.0 0.0 0.0 -0.23 -0.77 0.08
90639 BRD-K53581288 HCT116 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
90878 BRD-K53581288 MCF10A 10 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
96169 BRD-K53581288 A549 10 uM 24 h 0.27 1.15 0.32 0.0 0.0 0.0
96232 BRD-K53581288 U2OS 10 uM 24 h 0.23 0.97 0.08 0.28 0.97 0.36
97960 BRD-K53581288 P1A82 2.22 uM 24 h 0.23 0.95 0.06 0.36 1.27 1.34
98033 BRD-K53581288 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.21 -0.72 0.04
121564 BRD-K53581288 A375 3.33 uM 24 h -0.28 -1.18 0.5 0.0 0.0 0.0
121606 BRD-K53581288 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.4 -1.35 2.01
121641 BRD-K53581288 HELA 0.04 uM 24 h 0.0 0.0 0.0 0.33 1.18 0.98
129638 BRD-K53581288 HT29 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129697 BRD-K53581288 PC3 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129730 BRD-K53581288 YAPC 2.22 uM 24 h 0.25 1.03 0.13 0.33 1.17 0.93
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).