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CMap Candidate Details

Structure:
CMap ID: C00608
Pert ID: BRD-K62387885
Compound Name: basimglurant
Targets: GRM5
MoA: glutamate receptor antagonist
SMILES: Cc1nc(C#Cc2ccnc(Cl)c2)c(C)n1-c1ccc(F)cc1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
124572 BRD-K62387885 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124610 BRD-K62387885 HA1E 10 uM 24 h 0.25 1.04 0.14 0.0 0.0 0.0
124653 BRD-K62387885 HELA 10 uM 24 h 0.0 0.0 0.0 0.29 1.04 0.56
124684 BRD-K62387885 HT29 10 uM 24 h -0.24 -1.0 0.14 -0.27 -0.91 0.3
124718 BRD-K62387885 JURKAT 0.04 uM 24 h -0.2 -0.83 0.0 0.0 0.0 0.0
124755 BRD-K62387885 MCF??7.00 10 uM 24 h 0.27 1.14 0.31 0.0 0.0 0.0
124786 BRD-K62387885 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.29 1.03 0.52
124829 BRD-K62387885 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124909 BRD-K62387885 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132681 BRD-K62387885 A549 0.03 uM 24 h 0.21 0.87 0.01 0.3 1.06 0.59
132743 BRD-K62387885 HEK293 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132862 BRD-K62387885 MCF10A 0.25 uM 24 h 0.24 1.0 0.11 -0.27 -0.9 0.28
132927 BRD-K62387885 THP1 0.01 uM 24 h 0.0 0.0 0.0 -0.3 -1.01 0.56
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).