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CMap Candidate Details

Structure:
CMap ID: C00648
Pert ID: BRD-A80017228
Compound Name: bendroflumethiazide
Targets: CA1|CA2|CA4|KCNMA1|SLC12A1|SLC12A3
MoA: sodium/potassium/chloride transporter inhibitor
SMILES: NS(=O)(=O)c1cc2c(NC(Cc3ccccc3)NS2(=O)=O)cc1C(F)(F)F
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5167 BRD-A80017228 A375 10 uM 6 h 0.0 0.0 0.0 -0.33 -1.11 0.92
5552 BRD-A80017228 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
6153 BRD-A80017228 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
39412 BRD-A80017228 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
39595 BRD-A80017228 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
39915 BRD-A80017228 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
40718 BRD-A80017228 NEU 10 uM 24 h -0.19 -0.79 0.0 -0.33 -1.1 0.88
41019 BRD-A80017228 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41342 BRD-A80017228 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
50990 BRD-A80017228 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
100337 BRD-A80017228 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
127450 BRD-A80017228 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.41 -1.38 2.02
127478 BRD-A80017228 HELA 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127541 BRD-A80017228 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127714 BRD-A80017228 YAPC 1.11 uM 24 h -0.23 -0.96 0.1 -0.46 -1.55 15.35
135420 BRD-A80017228 HT29 0.03 uM 24 h 0.27 1.13 0.28 0.0 0.0 0.0
135454 BRD-A80017228 MCF10A 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135484 BRD-A80017228 MCF??7.00 0.74 uM 24 h 0.24 0.99 0.1 0.0 0.0 0.0
135510 BRD-A80017228 THP1 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).