CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C00678
Pert ID:	BRD-K21450440
Compound Name:	benzthiazide
Targets:	CA1\|CA12\|CA2\|CA4\|CA9\|SLC12A3
MoA:	carbonic anhydrase inhibitor
SMILES:	NS(=O)(=O)c1cc2c(cc1Cl)N=C(CSCc1ccccc1)NS2(=O)=O
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
5594	BRD-K21450440	HCC515	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
6338	BRD-K21450440	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
37612	BRD-K21450440	ASC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
37880	BRD-K21450440	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
38442	BRD-K21450440	NPC	10 uM	24 h	0.23	0.96	0.07	0.0	0.0	0.0
38923	BRD-K21450440	SKB	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
99743	BRD-K21450440	U2OS	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
120859	BRD-K21450440	A375	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
120905	BRD-K21450440	HA1E	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
120942	BRD-K21450440	HEK293	1.11 uM	24 h	-0.22	-0.93	0.07	0.21	0.76	0.05
120999	BRD-K21450440	HELA	0.125 uM	3 h	0.0	0.0	0.0	0.0	0.0	0.0
121034	BRD-K21450440	MCF??7.00	0.37 uM	24 h	0.2	0.85	0.01	0.0	0.0	0.0
121071	BRD-K21450440	PC3	0.37 uM	24 h	0.0	0.0	0.0	-0.23	-0.77	0.08
121100	BRD-K21450440	YAPC	0.125 uM	24 h	-0.34	-1.43	1.43	0.0	0.0	0.0
129110	BRD-K21450440	A549	0.74 uM	24 h	-0.24	-1.01	0.16	0.0	0.0	0.0
129186	BRD-K21450440	HT29	0.74 uM	24 h	-0.24	-1.0	0.15	0.0	0.0	0.0

Summary