CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C00069
Pert ID:	BRD-K43457670
Compound Name:	acetazolamide
Targets:	AQP1\|CA1\|CA12\|CA14\|CA2\|CA3\|CA4\|CA7
MoA:	carbonic anhydrase inhibitor
SMILES:	CC(=O)Nc1nnc(s1)S(N)(=O)=O
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
99541	BRD-K43457670	U2OS	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
123248	BRD-K43457670	A375	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
123434	BRD-K43457670	PC3	0.37 uM	24 h	-0.24	-0.98	0.12	0.0	0.0	0.0
123505	BRD-K43457670	YAPC	0.04 uM	24 h	0.18	0.75	0.0	0.0	0.0	0.0
131560	BRD-K43457670	A549	0.08 uM	24 h	0.0	0.0	0.0	0.31	1.1	0.69
131600	BRD-K43457670	HA1E	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131640	BRD-K43457670	HEK293	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131669	BRD-K43457670	HELA	0.08 uM	24 h	0.21	0.86	0.01	0.0	0.0	0.0
131690	BRD-K43457670	HT29	0.08 uM	24 h	0.0	0.0	0.0	0.26	0.93	0.28
131742	BRD-K43457670	HUVEC	2.22 uM	24 h	-0.29	-1.22	0.61	0.0	0.0	0.0
131796	BRD-K43457670	JURKAT	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131832	BRD-K43457670	MCF10A	0.74 uM	24 h	0.0	0.0	0.0	-0.27	-0.9	0.29
131870	BRD-K43457670	MCF??7.00	0.03 uM	24 h	0.0	0.0	0.0	-0.37	-1.25	1.35
131901	BRD-K43457670	MDAMB231	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131939	BRD-K43457670	THP1	0.08 uM	24 h	0.26	1.07	0.2	-0.26	-0.89	0.26

Summary