CMap Candidate Details
Structure:
| CMap ID: | C00690 |
| Pert ID: | BRD-K14796088 |
| Compound Name: | berberine |
| Targets: | LDLR |
| MoA: | LDL receptor activator |
| SMILES: | COc1ccc2cc3-c4cc5OCOc5cc4CC[n+]3cc2c1OC |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 122264 | BRD-K14796088 | A375 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 122286 | BRD-K14796088 | A549 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.33 | -1.11 | 0.91 |
| 122302 | BRD-K14796088 | HA1E | 3.33 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.26 | -0.88 | 0.25 |
| 122321 | BRD-K14796088 | HEK293 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 122334 | BRD-K14796088 | HELA | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 122345 | BRD-K14796088 | HT29 | 3.33 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 122369 | BRD-K14796088 | MCF10A | 3.33 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 122397 | BRD-K14796088 | MCF??7.00 | 10 uM | 24 h | -0.18 | -0.74 | 0.0 | -0.34 | -1.14 | 1.02 |
| 122445 | BRD-K14796088 | PC3 | 3.33 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 122487 | BRD-K14796088 | THP1 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.31 | 1.09 | 0.67 |
| 122522 | BRD-K14796088 | YAPC | 3.33 uM | 24 h | -0.18 | -0.74 | 0.0 | 0.0 | 0.0 | 0.0 |
| 130792 | BRD-K14796088 | MDAMB231 | 0.01 uM | 24 h | 0.18 | 0.75 | 0.0 | 0.0 | 0.0 | 0.0 |