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CMap Candidate Details

Structure:
CMap ID: C00705
Pert ID: BRD-K91315211
Compound Name: betahistine
Targets: HRH1|HRH3
MoA: histamine receptor agonist; histamine receptor antagonist
SMILES: CNCCc1ccccn1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4598 BRD-K91315211 HCC515 10 uM 6 h -0.23 -0.98 0.12 -0.21 -0.72 0.04
4970 BRD-K91315211 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.92 0.34
37758 BRD-K91315211 ASC 10 uM 24 h -0.32 -1.35 0.98 -0.35 -1.17 1.13
37955 BRD-K91315211 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38573 BRD-K91315211 NPC 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.93 0.35
38793 BRD-K91315211 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
39019 BRD-K91315211 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
96317 BRD-K91315211 A375 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127789 BRD-K91315211 A549 0.04 uM 24 h 0.2 0.84 0.0 0.0 0.0 0.0
127824 BRD-K91315211 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127869 BRD-K91315211 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127943 BRD-K91315211 HUVEC 3.33 uM 24 h -0.28 -1.15 0.43 -0.22 -0.73 0.05
127996 BRD-K91315211 MCF10A 3.33 uM 24 h 0.0 0.0 0.0 -0.24 -0.8 0.11
128053 BRD-K91315211 PC3 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128079 BRD-K91315211 YAPC 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135570 BRD-K91315211 HELA 0.01 uM 24 h 0.21 0.87 0.01 0.0 0.0 0.0
135615 BRD-K91315211 HT29 0.01 uM 24 h 0.35 1.44 1.12 0.28 0.99 0.4
135661 BRD-K91315211 JURKAT 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135697 BRD-K91315211 MCF??7.00 0.01 uM 24 h -0.19 -0.8 0.0 -0.23 -0.77 0.09
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).