CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C00721
Pert ID:	BRD-K46018455
Compound Name:	bezafibrate
Targets:	PPARA\|PPARD\|PPARG
MoA:	PPAR receptor agonist
SMILES:	CC(C)(Oc1ccc(CCNC(=O)c2ccc(Cl)cc2)cc1)C(O)=O
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
4434	BRD-K46018455	HCC515	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
5088	BRD-K46018455	VCAP	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
37670	BRD-K46018455	ASC	10 uM	24 h	0.0	0.0	0.0	-0.28	-0.95	0.41
37910	BRD-K46018455	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
38733	BRD-K46018455	PHH	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
38962	BRD-K46018455	SKB	10 uM	24 h	0.0	0.0	0.0	-0.36	-1.21	1.24
90991	BRD-K46018455	HUH7	10 uM	72 h	0.0	0.0	0.0	-0.22	-0.75	0.06
98901	BRD-K46018455	NEU	10 uM	24 h	-0.21	-0.89	0.03	0.26	0.92	0.24
99152	BRD-K46018455	NPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
99564	BRD-K46018455	U2OS	15 uM	6 h	-0.24	-1.0	0.15	0.0	0.0	0.0
125587	BRD-K46018455	A375	10 uM	24 h	0.25	1.04	0.14	0.28	1.01	0.44
125616	BRD-K46018455	A549	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125698	BRD-K46018455	HT29	0.37 uM	24 h	0.3	1.26	0.56	0.0	0.0	0.0
125739	BRD-K46018455	HUVEC	10 uM	24 h	0.0	0.0	0.0	-0.33	-1.11	0.9
125780	BRD-K46018455	JURKAT	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125830	BRD-K46018455	MCF??7.00	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125877	BRD-K46018455	PC3	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125896	BRD-K46018455	THP1	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125937	BRD-K46018455	YAPC	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133703	BRD-K46018455	HA1E	0.08 uM	24 h	0.0	0.0	0.0	0.3	1.05	0.57
133734	BRD-K46018455	HEK293	0.25 uM	24 h	-0.28	-1.18	0.51	0.0	0.0	0.0
133771	BRD-K46018455	HELA	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133861	BRD-K46018455	MCF10A	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133916	BRD-K46018455	MDAMB231	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary