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CMap Candidate Details

Structure:
CMap ID: C00754
Pert ID: BRD-A00546892
Compound Name: biperiden
Targets: CHRM1|CHRM2|CHRM3|CHRM4|CHRM5|CHRNA2
MoA: acetylcholine receptor antagonist
SMILES: OC(CCN1CCCCC1)(C1CC2CC1C=C2)c1ccccc1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5140 BRD-A00546892 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
5483 BRD-A00546892 HCC515 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.98 0.48
5813 BRD-A00546892 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.35 1.23 1.19
6389 BRD-A00546892 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.36 -1.2 1.22
37421 BRD-A00546892 ASC 10 uM 24 h -0.21 -0.89 0.03 0.0 0.0 0.0
38275 BRD-A00546892 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38587 BRD-A00546892 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38805 BRD-A00546892 SKB 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.02 0.62
122854 BRD-A00546892 HA1E 1.11 uM 24 h 0.0 0.0 0.0 -0.26 -0.88 0.25
122878 BRD-A00546892 HEK293 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122930 BRD-A00546892 HELA 3.33 uM 24 h 0.0 0.0 0.0 -0.29 -0.97 0.46
122962 BRD-A00546892 HT29 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123003 BRD-A00546892 JURKAT 3.33 uM 24 h -0.29 -1.21 0.59 0.0 0.0 0.0
123092 BRD-A00546892 MDAMB231 0.37 uM 24 h 0.0 0.0 0.0 -0.3 -1.0 0.53
123164 BRD-A00546892 THP1 0.37 uM 24 h 0.0 0.0 0.0 0.23 0.81 0.08
131229 BRD-A00546892 A549 0.01 uM 24 h -0.24 -1.0 0.14 0.0 0.0 0.0
131340 BRD-A00546892 HUVEC 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131390 BRD-A00546892 MCF10A 0.08 uM 24 h -0.2 -0.84 0.01 -0.24 -0.82 0.15
131424 BRD-A00546892 MCF??7.00 0.08 uM 24 h 0.16 0.68 0.0 -0.2 -0.68 0.02
131453 BRD-A00546892 PC3 0.74 uM 24 h -0.24 -1.0 0.14 -0.38 -1.27 1.41
131483 BRD-A00546892 YAPC 0.25 uM 24 h 0.26 1.08 0.21 0.3 1.06 0.58
136438 BRD-A00546892 SHSY5Y 10 uM 24 h 0.27 1.14 0.32 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).