CMap Candidate Details
Structure:
| CMap ID: | C00759 |
| Pert ID: | BRD-K06543683 |
| Compound Name: | bisindolylmaleimide-ix |
| Targets: | AKT1|GSK3B|LCK|MAPK1|MAPK11|MAPK12|MAPK14|MAPK8|PRKCA|ROCK1|RPS6KB1|SIRT1 |
| MoA: | PKC inhibitor |
| SMILES: | Cn1cc(C2=C(C(=O)NC2=O)c2cn(CCCSC(N)=N)c3ccccc23)c2ccccc12 |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 5425 | BRD-K06543683 | HA1E | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 5571 | BRD-K06543683 | HCC515 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 6258 | BRD-K06543683 | PC3 | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.26 | 0.92 | 0.25 |
| 39296 | BRD-K06543683 | A549 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 39623 | BRD-K06543683 | ASC | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 39944 | BRD-K06543683 | HEPG2 | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.24 | 0.86 | 0.15 |
| 40224 | BRD-K06543683 | HT29 | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.3 | 1.07 | 0.62 |
| 40587 | BRD-K06543683 | MCF??7.00 | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 40747 | BRD-K06543683 | NEU | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 41375 | BRD-K06543683 | SKB | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 97335 | BRD-K06543683 | HAP1 | 3.33 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 97343 | BRD-K06543683 | A375 | 0.66 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 100013 | BRD-K06543683 | U2OS | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |