CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C00766
Pert ID:	BRD-A89175223
Compound Name:	bisoprolol
Targets:	ADRB1\|ADRB2
MoA:	adrenergic receptor antagonist
SMILES:	CC(C)NCC(O)COc1ccc(COCCOC(C)C)cc1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
5559	BRD-A89175223	HCC515	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
25310	BRD-A89175223	VCAP	10 uM	24 h	0.0	0.0	0.0	-0.26	-0.88	0.24
37562	BRD-A89175223	ASC	10 uM	24 h	0.0	0.0	0.0	-0.27	-0.92	0.33
37861	BRD-A89175223	HEPG2	10 uM	6 h	0.0	0.0	0.0	-0.42	-1.4	2.02
38403	BRD-A89175223	NPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
38894	BRD-A89175223	SKB	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
127349	BRD-A89175223	A375	0.125 uM	24 h	-0.23	-0.96	0.1	0.0	0.0	0.0
127389	BRD-A89175223	A549	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
127422	BRD-A89175223	HA1E	0.04 uM	24 h	-0.21	-0.89	0.04	0.0	0.0	0.0
127463	BRD-A89175223	HELA	3.33 uM	24 h	0.28	1.16	0.36	0.0	0.0	0.0
127512	BRD-A89175223	JURKAT	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
127572	BRD-A89175223	MCF??7.00	1.11 uM	24 h	-0.29	-1.19	0.55	0.0	0.0	0.0
127604	BRD-A89175223	PC3	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
127644	BRD-A89175223	THP1	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
127682	BRD-A89175223	YAPC	0.125 uM	24 h	-0.18	-0.76	0.0	0.27	0.96	0.34
135399	BRD-A89175223	HT29	2.22 uM	24 h	0.0	0.0	0.0	-0.37	-1.26	1.35
135437	BRD-A89175223	MCF10A	0.08 uM	24 h	0.0	0.0	0.0	0.35	1.22	1.18

Summary