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CMap Candidate Details

Structure:
CMap ID: C00769
Pert ID: BRD-K13756951
Compound Name: bitopertin
Targets: SLC6A5|SLC6A9
MoA: glycine transporter inhibitor; GlyT-1 inhibitor
SMILES: C[C@H](Oc1ccc(cc1C(=O)N1CCN(CC1)c1ncc(cc1F)C(F)(F)F)S(C)(=O)=O)C(F)(F)F
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
122254 BRD-K13756951 A375 3.33 uM 24 h 0.0 0.0 0.0 -0.27 -0.9 0.28
122285 BRD-K13756951 A549 3.33 uM 24 h 0.27 1.11 0.26 0.0 0.0 0.0
122477 BRD-K13756951 THP1 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130592 BRD-K13756951 HA1E 2.22 uM 24 h 0.0 0.0 0.0 -0.37 -1.24 1.34
130626 BRD-K13756951 HEK293 0.01 uM 24 h 0.0 0.0 0.0 -0.23 -0.77 0.08
130669 BRD-K13756951 HELA 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130709 BRD-K13756951 HT29 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130740 BRD-K13756951 MCF10A 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130762 BRD-K13756951 MCF??7.00 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130784 BRD-K13756951 MDAMB231 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130813 BRD-K13756951 PC3 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130838 BRD-K13756951 YAPC 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).