CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C00792
Pert ID:	BRD-K43389698
Compound Name:	BMS-387032
Targets:	CDK2\|CDK7\|CDK9
MoA:	CDK inhibitor; cell cycle inhibitor; MCL1 inhibitor
SMILES:	CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCNCC3)s2)o1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
92436	BRD-K43389698	A549	0.04 uM	24 h	-0.21	-0.87	0.02	0.2	0.7	0.02
92466	BRD-K43389698	BT20	0.12 uM	24 h	-0.21	-0.87	0.02	0.0	0.0	0.0
92501	BRD-K43389698	HA1E	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
92535	BRD-K43389698	HME1	0.12 uM	24 h	0.21	0.89	0.02	0.0	0.0	0.0
92581	BRD-K43389698	HS578T	0.12 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
92670	BRD-K43389698	LNCAP	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
92736	BRD-K43389698	MCF10A	0.04 uM	3 h	0.0	0.0	0.0	0.0	0.0	0.0
92773	BRD-K43389698	MDAMB231	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
92827	BRD-K43389698	SKBR3	0.12 uM	24 h	-0.25	-1.04	0.21	0.0	0.0	0.0
96859	BRD-K43389698	A375	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
97278	BRD-K43389698	HAP1	0.66 uM	24 h	-0.27	-1.11	0.37	-0.27	-0.9	0.28
119667	BRD-K43389698	HEPG2	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
119705	BRD-K43389698	HT29	0.125 uM	24 h	0.22	0.94	0.05	0.31	1.08	0.66
119753	BRD-K43389698	JURKAT	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
119793	BRD-K43389698	MCF??7.00	0.125 uM	24 h	0.0	0.0	0.0	0.28	0.98	0.38
119826	BRD-K43389698	PC3	0.125 uM	24 h	0.0	0.0	0.0	-0.29	-0.97	0.46

Summary