CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C00814
Pert ID:	BRD-K31054881
Compound Name:	BMY-7378
Targets:	ADRA1A\|ADRA1B\|ADRA1D\|HTR1A
MoA:	adrenergic receptor antagonist; serotonin receptor antagonist
SMILES:	COc1ccccc1N1CCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
4212	BRD-K31054881	HA1E	10 uM	6 h	0.0	0.0	0.0	-0.32	-1.06	0.74
4409	BRD-K31054881	HCC515	10 uM	24 h	0.0	0.0	0.0	0.19	0.67	0.01
4796	BRD-K31054881	PC3	10 uM	6 h	0.0	0.0	0.0	-0.36	-1.2	1.17
5067	BRD-K31054881	VCAP	10 uM	6 h	0.0	0.0	0.0	-0.29	-0.98	0.48
39114	BRD-K31054881	A375	10 uM	6 h	-0.21	-0.9	0.04	0.31	1.09	0.68
39315	BRD-K31054881	A549	10 uM	24 h	0.0	0.0	0.0	0.33	1.18	0.98
39665	BRD-K31054881	ASC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
39978	BRD-K31054881	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
40254	BRD-K31054881	HT29	10 uM	6 h	-0.21	-0.88	0.03	-0.27	-0.91	0.31
40608	BRD-K31054881	MCF??7.00	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
40785	BRD-K31054881	NEU	10 uM	24 h	0.22	0.93	0.05	0.0	0.0	0.0
41086	BRD-K31054881	NPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
41419	BRD-K31054881	SKB	10 uM	24 h	0.0	0.0	0.0	0.34	1.21	1.15
99822	BRD-K31054881	U2OS	10 uM	6 h	0.0	0.0	0.0	0.24	0.84	0.12

Summary