CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C00084
Pert ID:	BRD-K62012036
Compound Name:	acitretin
Targets:	RARA\|RARB\|RARG\|RBP1\|RXRA\|RXRB\|RXRG\|STAT3
MoA:	retinoid receptor agonist
SMILES:	COc1cc(C)c(\C=C\C(C)=C\C=C\C(C)=C\C(O)=O)c(C)c1C
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
33665	BRD-K62012036	A375	10 uM	6 h	-0.23	-0.96	0.1	-0.36	-1.23	1.25
33818	BRD-K62012036	A549	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
34140	BRD-K62012036	ASC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
34391	BRD-K62012036	HA1E	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
34653	BRD-K62012036	HCC515	10 uM	6 h	0.29	1.21	0.44	0.32	1.12	0.78
34921	BRD-K62012036	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
35172	BRD-K62012036	HT29	10 uM	6 h	0.0	0.0	0.0	-0.24	-0.82	0.15
35445	BRD-K62012036	MCF??7.00	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
35591	BRD-K62012036	NEU	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
35975	BRD-K62012036	PC3	10 uM	24 h	0.0	0.0	0.0	-0.34	-1.14	1.01
36299	BRD-K62012036	PHH	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
36600	BRD-K62012036	SKB	10 uM	24 h	0.0	0.0	0.0	-0.25	-0.84	0.18
36845	BRD-K62012036	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
99170	BRD-K62012036	NPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary