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CMap Candidate Details

Structure:
CMap ID: C00843
Pert ID: BRD-K74913225
Compound Name: brinzolamide
Targets: CA1|CA12|CA14|CA2|CA4|CA5A|CA7
MoA: carbonic anhydrase inhibitor
SMILES: CCN[C@H]1CN(CCCOC)S(=O)(=O)c2sc(cc12)S(N)(=O)=O
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4251 BRD-K74913225 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
4482 BRD-K74913225 HCC515 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.97 0.45
4959 BRD-K74913225 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
44442 BRD-K74913225 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
44615 BRD-K74913225 A549 10 uM 24 h -0.25 -1.03 0.19 0.0 0.0 0.0
45022 BRD-K74913225 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
45314 BRD-K74913225 HEPG2 10 uM 6 h -0.24 -1.01 0.17 0.0 0.0 0.0
45574 BRD-K74913225 HT29 10 uM 6 h 0.0 0.0 0.0 0.29 1.03 0.52
46135 BRD-K74913225 NPC 10 uM 24 h -0.23 -0.94 0.08 -0.34 -1.16 1.1
46451 BRD-K74913225 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
46776 BRD-K74913225 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
51242 BRD-K74913225 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.21 0.76 0.05
51509 BRD-K74913225 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).