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CMap Candidate Details

Structure:
CMap ID: C00087
Pert ID: BRD-K74363950
Compound Name: aclidinium
Targets: CHRM1|CHRM2|CHRM3|CHRM4|CHRM5
MoA: acetylcholine receptor antagonist
SMILES: OC(C(=O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)(c1cccs1)c1cccs1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
126393 BRD-K74363950 HA1E 0.04 uM 24 h 0.0 0.0 0.0 0.26 0.92 0.25
126412 BRD-K74363950 HEK293 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126504 BRD-K74363950 MCF10A 0.125 uM 24 h 0.0 0.0 0.0 0.26 0.9 0.22
134336 BRD-K74363950 A375 0.03 uM 24 h 0.22 0.94 0.05 0.0 0.0 0.0
134365 BRD-K74363950 A549 0.01 uM 24 h 0.0 0.0 0.0 -0.27 -0.9 0.29
134415 BRD-K74363950 HELA 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134445 BRD-K74363950 HT29 0.74 uM 24 h 0.0 0.0 0.0 0.26 0.94 0.28
134479 BRD-K74363950 HUVEC 0.03 uM 24 h 0.21 0.86 0.01 0.38 1.35 1.72
134555 BRD-K74363950 MCF??7.00 0.01 uM 24 h 0.17 0.72 0.0 -0.28 -0.96 0.43
134582 BRD-K74363950 MDAMB231 0.03 uM 24 h 0.0 0.0 0.0 -0.29 -0.98 0.48
134612 BRD-K74363950 PC3 2.22 uM 24 h 0.0 0.0 0.0 -0.26 -0.88 0.25
134639 BRD-K74363950 YAPC 0.25 uM 24 h -0.2 -0.85 0.01 -0.21 -0.72 0.04
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).