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CMap Candidate Details

Structure:
CMap ID: C00901
Pert ID: BRD-A05186015
Compound Name: bupropion
Targets: CHRNA3|SLC6A2|SLC6A3
MoA: dopamine uptake inhibitor
SMILES: CC(NC(C)(C)C)C(=O)c1cccc(Cl)c1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5489 BRD-A05186015 HCC515 10 uM 24 h 0.0 0.0 0.0 -0.26 -0.89 0.27
5816 BRD-A05186015 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
6447 BRD-A05186015 VCAP 10 uM 6 h 0.23 0.96 0.08 0.3 1.05 0.57
37432 BRD-A05186015 ASC 10 uM 24 h 0.0 0.0 0.0 -0.36 -1.21 1.24
38286 BRD-A05186015 NPC 10 uM 24 h 0.0 0.0 0.0 -0.4 -1.34 1.85
91018 BRD-A05186015 HUH7 15 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
122674 BRD-A05186015 HT29 3.33 uM 24 h 0.23 0.97 0.08 -0.25 -0.84 0.18
122707 BRD-A05186015 MCF10A 0.37 uM 24 h -0.23 -0.97 0.11 0.2 0.7 0.02
130862 BRD-A05186015 A375 2.22 uM 24 h 0.25 1.06 0.18 0.0 0.0 0.0
130881 BRD-A05186015 A549 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130907 BRD-A05186015 HA1E 0.74 uM 24 h 0.0 0.0 0.0 -0.23 -0.77 0.08
130929 BRD-A05186015 HEK293 0.08 uM 24 h 0.0 0.0 0.0 -0.27 -0.91 0.31
130957 BRD-A05186015 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131029 BRD-A05186015 HUVEC 0.08 uM 24 h -0.25 -1.05 0.22 0.0 0.0 0.0
131078 BRD-A05186015 MCF??7.00 2.22 uM 24 h -0.17 -0.7 0.0 0.28 1.0 0.42
131111 BRD-A05186015 MDAMB231 0.08 uM 24 h -0.21 -0.89 0.03 -0.31 -1.04 0.68
131142 BRD-A05186015 PC3 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131176 BRD-A05186015 YAPC 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).