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CMap Candidate Details

Structure:
CMap ID: C00903
Pert ID: BRD-K93461745
Compound Name: buspirone
Targets: DRD2|HTR1A
MoA: serotonin receptor agonist
SMILES: O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5375 BRD-K93461745 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
5808 BRD-K93461745 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
39839 BRD-K93461745 ASC 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.1 0.87
40128 BRD-K93461745 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.22 0.79 0.07
40935 BRD-K93461745 NEU 10 uM 24 h -0.25 -1.02 0.18 -0.38 -1.27 1.43
41260 BRD-K93461745 NPC 10 uM 24 h 0.0 0.0 0.0 -0.25 -0.85 0.2
41600 BRD-K93461745 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
51195 BRD-K93461745 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91402 BRD-K93461745 HUH7 8 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
128114 BRD-K93461745 A375 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128233 BRD-K93461745 MCF10A 0.04 uM 24 h 0.0 0.0 0.0 -0.32 -1.08 0.81
128265 BRD-K93461745 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128312 BRD-K93461745 MDAMB231 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128357 BRD-K93461745 THP1 3.33 uM 24 h 0.0 0.0 0.0 -0.27 -0.92 0.34
135781 BRD-K93461745 A549 2.22 uM 24 h 0.0 0.0 0.0 0.26 0.92 0.26
135858 BRD-K93461745 HEK293 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135907 BRD-K93461745 HELA 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135948 BRD-K93461745 HT29 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135996 BRD-K93461745 JURKAT 0.01 uM 24 h 0.21 0.87 0.01 -0.37 -1.25 1.35
136065 BRD-K93461745 PC3 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136142 BRD-K93461745 YAPC 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).