CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C00923
Pert ID:	BRD-K28965160
Compound Name:	BVD-523
Targets:
MoA:	MAP kinase inhibitor
SMILES:	CC(C)Nc1cc(-c2c[nH]c(c2)C(=O)N[C@H](CO)c2cccc(Cl)c2)c(Cl)cn1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
121888	BRD-K28965160	A375	1.11 uM	24 h	0.0	0.0	0.0	-0.26	-0.87	0.23
121934	BRD-K28965160	HA1E	10 uM	24 h	0.24	0.99	0.09	-0.27	-0.91	0.3
121979	BRD-K28965160	HELA	3.33 uM	24 h	0.33	1.36	0.97	0.3	1.05	0.56
122004	BRD-K28965160	HT29	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
122040	BRD-K28965160	HUVEC	3.33 uM	24 h	0.0	0.0	0.0	-0.27	-0.9	0.29
122088	BRD-K28965160	MCF10A	10 uM	24 h	0.18	0.74	0.0	0.0	0.0	0.0
122135	BRD-K28965160	MDAMB231	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
122160	BRD-K28965160	PC3	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
122186	BRD-K28965160	THP1	3.33 uM	24 h	0.0	0.0	0.0	-0.26	-0.88	0.25
122214	BRD-K28965160	YAPC	3.33 uM	24 h	0.0	0.0	0.0	0.26	0.91	0.23
130198	BRD-K28965160	A549	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130252	BRD-K28965160	HEK293	0.01 uM	24 h	-0.26	-1.1	0.34	0.0	0.0	0.0
130342	BRD-K28965160	JURKAT	2.22 uM	24 h	0.29	1.21	0.47	0.22	0.78	0.07
130427	BRD-K28965160	MCF??7.00	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary