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CMap Candidate Details

Structure:
CMap ID: C00933
Pert ID: BRD-K49669041
Compound Name: BX-912
Targets: CDK2|CHEK1|GSK3B|KDR|PDK1|PDPK1
MoA: pyruvate dehydrogenase kinase inhibitor
SMILES: Brc1cnc(Nc2cccc(NC(=O)N3CCCC3)c2)nc1NCCc1c[nH]cn1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
33912 BRD-K49669041 A549 10 uM 6 h 0.0 0.0 0.0 -0.4 -1.35 2.02
34119 BRD-K49669041 ASC 10 uM 24 h 0.24 0.99 0.1 0.0 0.0 0.0
34634 BRD-K49669041 HCC515 10 uM 6 h -0.22 -0.91 0.05 -0.29 -0.97 0.46
34899 BRD-K49669041 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.36 -1.21 1.24
35157 BRD-K49669041 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
35576 BRD-K49669041 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
35794 BRD-K49669041 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36087 BRD-K49669041 PC3 10 uM 6 h 0.0 0.0 0.0 -0.26 -0.88 0.26
36576 BRD-K49669041 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
88559 BRD-K49669041 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.32 -1.08 0.81
92001 BRD-K49669041 A375 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92045 BRD-K49669041 BT20 10 uM 3 h -0.22 -0.92 0.06 -0.4 -1.34 1.86
92077 BRD-K49669041 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92166 BRD-K49669041 HS578T 10 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
92241 BRD-K49669041 MCF10A 10 uM 3 h 0.0 0.0 0.0 -0.35 -1.18 1.14
92261 BRD-K49669041 MCF??7.00 10 uM 24 h -0.27 -1.11 0.36 0.0 0.0 0.0
92317 BRD-K49669041 MDAMB231 3.33 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
92394 BRD-K49669041 SKBR3 10 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
96006 BRD-K49669041 PHH 10 uM 24 h -0.25 -1.06 0.25 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).