CMap Candidate Details
Structure:
| CMap ID: | C00940 |
| Pert ID: | BRD-K06858286 |
| Compound Name: | cabazitaxel |
| Targets: | TUBA4A|TUBB|TUBB1 |
| MoA: | microtubule inhibitor |
| SMILES: | CO[C@@H]1C[C@H]2OC[C@@]2(OC(C)=O)[C@H]2[C@@H](OC(=O)c3ccccc3)[C@@]3(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C(C)=C([C@@H](OC)C(=O)[C@]12C)C3(C)C |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 122578 | BRD-K06858286 | A549 | 3.33 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 122722 | BRD-K06858286 | MCF10A | 1.11 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 122794 | BRD-K06858286 | PC3 | 1.11 uM | 24 h | -0.28 | -1.18 | 0.5 | -0.31 | -1.05 | 0.71 |
| 130868 | BRD-K06858286 | A375 | 0.74 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 130915 | BRD-K06858286 | HA1E | 2.22 uM | 24 h | -0.23 | -0.94 | 0.08 | -0.43 | -1.45 | 15.35 |
| 130936 | BRD-K06858286 | HEK293 | 0.08 uM | 24 h | -0.24 | -1.01 | 0.17 | -0.42 | -1.41 | 2.02 |
| 130968 | BRD-K06858286 | HELA | 0.03 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 131001 | BRD-K06858286 | HT29 | 0.01 uM | 24 h | -0.28 | -1.15 | 0.44 | 0.0 | 0.0 | 0.0 |
| 131044 | BRD-K06858286 | HUVEC | 0.08 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 131083 | BRD-K06858286 | MCF??7.00 | 0.01 uM | 24 h | 0.26 | 1.09 | 0.24 | -0.26 | -0.88 | 0.26 |
| 131119 | BRD-K06858286 | MDAMB231 | 0.08 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.29 | -0.99 | 0.51 |
| 131185 | BRD-K06858286 | YAPC | 0.03 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.28 | -0.93 | 0.35 |