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CMap Candidate Details

Structure:
CMap ID: C00943
Pert ID: BRD-K51544265
Compound Name: cabozantinib
Targets: KDR|MET
MoA: RET tyrosine kinase inhibitor; VEGFR inhibitor
SMILES: COc1cc2nccc(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3)c2cc1OC
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1175 BRD-K51544265 PC3 10 uM 24 h -0.19 -0.8 0.0 0.0 0.0 0.0
1274 BRD-K51544265 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
1328 BRD-K51544265 U2OS 10 uM 24 h -0.2 -0.85 0.01 -0.37 -1.26 1.38
92920 BRD-K51544265 ASC 10 uM 24 h 0.0 0.0 0.0 0.24 0.83 0.12
92980 BRD-K51544265 CD34 0.37 uM 24 h -0.34 -1.41 1.25 0.28 1.01 0.44
93033 BRD-K51544265 HA1E 0.37 uM 24 h 0.0 0.0 0.0 -0.26 -0.87 0.23
93157 BRD-K51544265 HEPG2 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93206 BRD-K51544265 HUVEC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93263 BRD-K51544265 JURKAT 10 uM 24 h -0.24 -0.99 0.13 0.3 1.06 0.59
93388 BRD-K51544265 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93507 BRD-K51544265 SKL 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95333 BRD-K51544265 A549 10 uM 6 h -0.31 -1.3 0.8 0.0 0.0 0.0
124270 BRD-K51544265 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124338 BRD-K51544265 HELA 10 uM 24 h 0.0 0.0 0.0 0.33 1.18 1.01
124377 BRD-K51544265 HT29 10 uM 24 h -0.18 -0.77 0.0 0.26 0.92 0.25
124477 BRD-K51544265 MDAMB231 10 uM 24 h -0.17 -0.72 0.0 0.0 0.0 0.0
124534 BRD-K51544265 YAPC 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132409 BRD-K51544265 HEK293 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132482 BRD-K51544265 MCF10A 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132587 BRD-K51544265 THP1 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).