Logo 1 Logo 2

CMap Candidate Details

Structure:
CMap ID: C00962
Pert ID: BRD-K37890730
Compound Name: camptothecin
Targets: TOP1
MoA: topoisomerase inhibitor
SMILES: CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccccc4cc3Cn1c2=O
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1150 BRD-K37890730 A549 0.12 uM 24 h -0.22 -0.93 0.07 0.0 0.0 0.0
1324 BRD-K37890730 U2OS 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
51319 BRD-K37890730 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
88552 BRD-K37890730 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
90891 BRD-K37890730 MCF10A 1.11 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
90994 BRD-K37890730 HUH7 10 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
119895 BRD-K37890730 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
119918 BRD-K37890730 PC3 0.125 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
123272 BRD-K37890730 HA1E 0.125 uM 24 h 0.25 1.04 0.14 0.0 0.0 0.0
123333 BRD-K37890730 HT29 0.125 uM 24 h 0.21 0.89 0.02 0.28 1.0 0.42
123484 BRD-K37890730 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131524 BRD-K37890730 A375 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131616 BRD-K37890730 HEK293 0.25 uM 24 h 0.25 1.05 0.18 0.0 0.0 0.0
131651 BRD-K37890730 HELA 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131709 BRD-K37890730 HUVEC 0.01 uM 24 h 0.0 0.0 0.0 -0.35 -1.18 1.14
131762 BRD-K37890730 JURKAT 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131881 BRD-K37890730 MDAMB231 0.03 uM 24 h 0.0 0.0 0.0 0.39 1.38 2.14
131927 BRD-K37890730 THP1 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).