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CMap Candidate Details

Structure:
CMap ID: C00968
Pert ID: BRD-K50168500
Compound Name: canertinib
Targets: AKT1|EGFR|ERBB2|ERBB4
MoA: EGFR inhibitor
SMILES: Fc1ccc(Nc2ncnc3cc(OCCCN4CCOCC4)c(NC(=O)C=C)cc23)cc1Cl
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
486 BRD-K50168500 BJAB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
551 BRD-K50168500 HBL1 10 uM 4 h 0.0 0.0 0.0 -0.47 -1.58 15.65
593 BRD-K50168500 K562 2.5 uM 4 h -0.24 -0.99 0.14 0.29 1.02 0.49
624 BRD-K50168500 KMS34 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
669 BRD-K50168500 MINO 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
717 BRD-K50168500 NALM6 2.5 uM 24 h 0.0 0.0 0.0 -0.24 -0.81 0.14
755 BRD-K50168500 OCILY19 0.66 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
827 BRD-K50168500 OCILY3 10 uM 4 h 0.0 0.0 0.0 -0.42 -1.43 15.35
858 BRD-K50168500 SKMEL5 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.91 0.31
958 BRD-K50168500 TMD8 10 uM 4 h -0.22 -0.91 0.05 0.32 1.13 0.82
33718 BRD-K50168500 A375 10 uM 6 h 0.0 0.0 0.0 0.28 1.0 0.42
34121 BRD-K50168500 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
34637 BRD-K50168500 HCC515 10 uM 6 h -0.23 -0.96 0.1 0.36 1.26 1.29
35159 BRD-K50168500 HT29 10 uM 6 h -0.2 -0.81 0.0 0.4 1.41 2.19
35579 BRD-K50168500 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
35796 BRD-K50168500 NPC 10 uM 24 h 0.0 0.0 0.0 0.34 1.22 1.15
36281 BRD-K50168500 PHH 10 uM 24 h 0.0 0.0 0.0 0.24 0.86 0.15
36579 BRD-K50168500 SKB 10 uM 24 h 0.0 0.0 0.0 0.29 1.01 0.45
36830 BRD-K50168500 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.0 0.53
91860 BRD-K50168500 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91938 BRD-K50168500 SKBR3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92435 BRD-K50168500 A549 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92465 BRD-K50168500 BT20 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92500 BRD-K50168500 HA1E 1.11 uM 24 h 0.0 0.0 0.0 -0.26 -0.88 0.25
92558 BRD-K50168500 HME1 10 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
92580 BRD-K50168500 HS578T 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92669 BRD-K50168500 LNCAP 3.33 uM 24 h 0.28 1.19 0.41 0.0 0.0 0.0
92735 BRD-K50168500 MCF10A 0.04 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
95640 BRD-K50168500 U2OS 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
115788 BRD-K50168500 HEPG2 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
115916 BRD-K50168500 PC3 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124633 BRD-K50168500 HEK293 10 uM 24 h -0.29 -1.21 0.59 0.0 0.0 0.0
124646 BRD-K50168500 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124713 BRD-K50168500 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124775 BRD-K50168500 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124866 BRD-K50168500 THP1 10 uM 24 h 0.0 0.0 0.0 -0.4 -1.35 2.01
124904 BRD-K50168500 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).