Investigational Drug Details
| Drug ID: | D215 |
| Drug Name: | Hydrocortisone |
| Synonyms: | |
| Type: | small molecule |
| DrugBank ID: | DB00741 |
| DrugBank Description: | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex.[A188387] Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone.[A188420] Hydrocortisone was granted FDA approval on 5 August 1952.[L10574] |
| PubChem ID: | 5754 |
| CasNo: | 50-23-7 |
| Repositioning for NAFLD: | Yes |
| SMILES: | [H][C@@]12CC[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C |
| Structure: |
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| InChiKey: | JYGXADMDTFJGBT-VWUMJDOOSA-N |
| Molecular Weight: | 362.4599 |
| DrugBank Targets: | Glucocorticoid receptor; Annexin A1 |
| DrugBank MoA: | The short term effects of corticosteroids are decreased vasodilation and permeability of capillaries, as well as decreased leukocyte migration to sites of inflammation.[A187463] Corticosteroids binding to the glucocorticoid receptor mediates changes in gene expression that lead to multiple downstream effects over hours to days.[A187463] Glucocorticoids inhibit neutrophil apoptosis and demargination; they inhibit phospholipase A2, which decreases the formation of arachidonic acid derivatives; they inhibit NF-Kappa B and other inflammatory transcription factors; they promote anti-inflammatory genes like interleukin-10.[A187463] Lower doses of corticosteroids provide an anti-inflammatory effect, while higher doses are immunosuppressive.[A187463] High doses of glucocorticoids for an extended period bind to the mineralocorticoid receptor, raising sodium levels and decreasing potassium levels.[A187463] |
| DrugBank Pharmacology: | Hydrocortisone binds to the glucocorticoid receptor leading to downstream effects such as inhibition of phospholipase A2, NF-kappa B, other inflammatory transcription factors, and the promotion of anti-inflammatory genes.[A187463] Hydrocortisone has a wide therapeutic index[A188405] and a moderate duration of action.[A188354,A188381] Patients should stop taking the medication if irritation or sensitization occurs.[L10529,L10532,L10535,L10538,L7772,L7321] |
| DrugBank Indication: | Otic solutions are indicated for infections of the external auditory canal caused by susceptible organisms and with inflammation.[L10529,L10532] Hydrocortisone tablets are indicated for certain endocrine, rheumatic, collagen, allergic, ophthalmic, respiratory, hematologic, neoplastic, edematous, gastrointestinal, and other conditions.[L10535] A hydrocortisone enema is indicated for ulcerative colitis,[L10538] a topical ointment with antibiotics is indicated for corticosteroid responsive dermatoses with infections,[L7772] and a topical cream with [acyclovir] is indicated to treat cold sores.[L7321] |
| Targets: | |
| Therapeutic Category: | |
| Clinical Trial Progress: | |
| Latest Progress: |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L4892 | NCT06192108 | PHASE3 | ACTIVE_NOT_RECRUITING | NO | 2024-01-10 | 2025-02-28 | Details |
| L7178 | NCT00982254 | PHASE1 | COMPLETED | NO | 2001-10 | 2009-09-23 | Details |
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