Investigational Drug Details
| Drug ID: | D256 |
| Drug Name: | Isosorbide dinitrate |
| Synonyms: | |
| Type: | small molecule |
| DrugBank ID: | DB00883 |
| DrugBank Description: | A vasodilator used in the treatment of angina pectoris. Its actions are similar to nitroglycerin but with a slower onset of action. |
| PubChem ID: | 6883 |
| CasNo: | 87-33-2 |
| Repositioning for NAFLD: | Yes |
| SMILES: | [H][C@]12OC[C@H](O[N+]([O-])=O)[C@@]1([H])OC[C@H]2O[N+]([O-])=O |
| Structure: |
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| InChiKey: | MOYKHGMNXAOIAT-JGWLITMVSA-N |
| Molecular Weight: | 236.1363 |
| DrugBank Targets: | Atrial natriuretic peptide receptor 1 |
| DrugBank MoA: | Isosorbide dinitrate is converted to the active nitric oxide to activate guanylate cyclase. This activation increases levels of cyclic guanosine 3',5'-monophosphate (cGMP). cGMP activates protein kinases and causes a series of phosphorylation reactions which leads to dephosphorylation of myosin light chains of smooth muscle fibres. Finally there is a release of calcium ions which causes smooth muscle relaxation and vasodilation. |
| DrugBank Pharmacology: | Isosorbide Dinitrate is a moderate to long acting oral organic nitrate used for the relief and prophylactic management of angina pectoris. It relaxes the vascular smooth muscle and consequent dilatation of peripheral arteries and veins, especially the latter. Dilatation of the veins promotes peripheral pooling of blood and decreases venous return to the heart, thereby reducing left ventricular end- diastolic pressure and pulmonary capillary wedge pressure (preload). Arteriolar relaxation reduces systemic vascular resistance, systolic arterial pressure, and mean arterial pressure. |
| DrugBank Indication: | For the prevention of angina pectoris due to coronary artery disease. |
| Targets: | |
| Therapeutic Category: | |
| Clinical Trial Progress: | |
| Latest Progress: |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L3921 | NCT06256523 | PHASE1|PHASE2 | COMPLETED | NO | 2022-06-29 | 2024-02-23 | Details |
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