Investigational Drug Details
| Drug ID: | D266 |
| Drug Name: | Dinoprostone |
| Synonyms: | |
| Type: | small molecule |
| DrugBank ID: | DB00917 |
| DrugBank Description: | Dinoprostone is a naturally occurring prostaglandin E2 (PGE2). It has important effects in labour. It also stimulates osteoblasts to release factors which stimualtes bone resorption by osteoclasts. As a prescription drug it is used as a vaginal suppository, to prepare the cervix for labour and to induce labour. |
| PubChem ID: | 5280360 |
| CasNo: | 363-24-6 |
| Repositioning for NAFLD: | Yes |
| SMILES: | CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O |
| Structure: |
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| InChiKey: | XEYBRNLFEZDVAW-ARSRFYASSA-N |
| Molecular Weight: | 352.4651 |
| DrugBank Targets: | Prostaglandin E2 receptor EP2 subtype; Prostaglandin E2 receptor EP1 subtype; Prostaglandin E2 receptor EP3 subtype; Prostaglandin E2 receptor EP4 subtype; Prostaglandin D2 receptor 2 |
| DrugBank MoA: | Dinoprostone administered intravaginally stimulates the myometrium of the gravid uterus to contract in a manner that is similar to the contractions seen in the term uterus during labor, resulting in the evacuation of the products of conception from the uterus. It is believed that dinoprostone exerts its uterine effects via direct myometrial stimulation, but the exact mechanism of action is unkown. Other suggested mechanisms include the regulation of cellular membrane calcium transport and of intracellular concentrations of cyclic 3',5'-adenosine monophosphate. Dinoprostone also appears to produce local cervical effects including softening, effacement, and dilation. The exact mechanism of action for this effect is also unknown, but it has been suggested that this effect may be associated with collagen degradation caused by secretion of the enzyme collagenase as a partial response to locally administered dinoprostone. |
| DrugBank Pharmacology: | Dinoprostone is equivalent to prostaglandin E2 (PGE2). It stimulates labor and delivery by stimulating the uterine, and thus terminates pregnancy. Dinoprostone is also capable of stimulating the smooth muscle of the gastrointestinal tract of man. This activity may be responsible for the vomiting and/or diarrhea that is not uncommon when dinoprostone is used to terminate pregnancy. |
| DrugBank Indication: | For the termination of pregnancy during the second trimester (from the 12th through the 20th gestational week as calculated from the first day of the last normal menstrual period), as well as for evacuation of the uterine contents in the management of missed abortion or intrauterine fetal death up to 28 weeks of gestational age as calculated from the first day of the last normal menstrual period. Also used in the management of nonmetastatic gestational trophoblastic disease (benign hydatidiform mole). Other indications include improving the cervical inducibility (cervical "ripening") in pregnant women at or near term with a medical or obstetrical need for labor induction, and the management of postpartum hemorrhage. |
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