Investigational Drug Details
| Drug ID: | D339 |
| Drug Name: | Cefadroxil |
| Synonyms: | |
| Type: | small molecule |
| DrugBank ID: | DB01140 |
| DrugBank Description: | Long-acting, broad-spectrum, water-soluble, cephalexin derivative. |
| PubChem ID: | 47965 |
| CasNo: | 50370-12-2 |
| Repositioning for NAFLD: | Yes |
| SMILES: | [H][C@]12SCC(C)=C(N1C(=O)[C@H]2NC(=O)[C@H](N)C1=CC=C(O)C=C1)C(O)=O |
| Structure: |
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| InChiKey: | BOEGTKLJZSQCCD-UEKVPHQBSA-N |
| Molecular Weight: | 363.388 |
| DrugBank Targets: | Penicillin-binding protein 3; Penicillin-binding protein 1A; Penicillin-binding protein 1b; Penicillin-binding protein 2B |
| DrugBank MoA: | Like all beta-lactam antibiotics, cefadroxil binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, causing the inhibition of the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefadroxil interferes with an autolysin inhibitor. |
| DrugBank Pharmacology: | Cefadroxil, a first-generation cephalosporin antibiotic, is used to treat urinary tract infections, skin and skin structure infections, pharyngitis, and tonsillitis. |
| DrugBank Indication: | For the treatment of the following infections (skin, UTI, ENT) caused by; <i>S. pneumoniae, H. influenzae, staphylococci, S. pyogenes</i> (group A beta-hemolytic streptococci), <i>E. coli, P. mirabilis, Klebsiella</i> sp, coagulase-negative staphylococci and <i>Streptococcus pyogenes</i> |
| Targets: | |
| Therapeutic Category: | |
| Clinical Trial Progress: | |
| Latest Progress: |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L4019 | NCT02516150 | PHASE4 | COMPLETED | YES | 2016-03 | 2017-08-31 | Details |
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