Investigational Drug Details
| Drug ID: | D345 |
| Drug Name: | Chlormezanone |
| Synonyms: | |
| Type: | small molecule |
| DrugBank ID: | DB01178 |
| DrugBank Description: | A non-benzodiazepine that is used in the management of anxiety. It has been suggested for use in the treatment of muscle spasm. |
| PubChem ID: | 2717 |
| CasNo: | 80-77-3 |
| Repositioning for NAFLD: | Yes |
| SMILES: | CN1C(C2=CC=C(Cl)C=C2)S(=O)(=O)CCC1=O |
| Structure: |
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| InChiKey: | WEQAYVWKMWHEJO-UHFFFAOYSA-N |
| Molecular Weight: | 273.736 |
| DrugBank Targets: | Translocator protein |
| DrugBank MoA: | Chlormezanone binds to central benzodiazepine receptors which interact allosterically with GABA receptors. This potentiates the effects of the inhibitory neurotransmitter GABA, increasing the inhibition of the ascending reticular activating system and blocking the cortical and limbic arousal that occurs following stimulation of the reticular pathways. |
| DrugBank Pharmacology: | Chlormezanone is a non-benzodiazepine muscle relaxant. It was discontinued worldwide in 1996 by its manufacturer due to confirmed serious and rare cutaneous reactions (toxic epidermal necrolysis). |
| DrugBank Indication: | Used in the management of anxiety and in the treatment of muscle spasm. |
| Targets: | |
| Therapeutic Category: | |
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