Investigational Drug Details
| Drug ID: | D478 |
| Drug Name: | Dimethyl fumarate |
| Synonyms: | |
| Type: | small molecule |
| DrugBank ID: | DB08908 |
| DrugBank Description: | Dimethyl fumarate is an anti-inflammatory. It is indicated for multiple sclerosis patients with relapsing forms and is also being investigated for the treatment of psoriasis. The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MMF up-regulates the Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway that is activated in response to oxidative stress. Dimethyl fumarate is marketed under the brand name Tecfidera. |
| PubChem ID: | 637568 |
| CasNo: | 624-49-7 |
| Repositioning for NAFLD: | Yes |
| SMILES: | [H]\C(=C(\[H])C(=O)OC)C(=O)OC |
| Structure: |
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| InChiKey: | LDCRTTXIJACKKU-ONEGZZNKSA-N |
| Molecular Weight: | 144.1253 |
| DrugBank Targets: | Kelch-like ECH-associated protein 1; Transcription factor p65 |
| DrugBank MoA: | The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF). MMF up-regulates the Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway that is activated in response to oxidative stress. As well MMF is an agonist at the nicotinic acid receptor, but the relevance of this is not known. |
| DrugBank Pharmacology: | The physiological effects dimethyl fumarate has on the body is not well understood. It is known that dimethyl fumarate has anti-inflammatory and cytoprotective effects, which both are likely involved in its actions in multiple sclerosis patients. |
| DrugBank Indication: | Used in multiple sclerosis patients with relapsing forms. |
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