Investigational Drug Details
| Drug ID: | D013 |
| Drug Name: | Ornithine |
| Synonyms: | |
| Type: | small molecule |
| DrugBank ID: | DB00129 |
| DrugBank Description: | Produced during the urea cycle, ornithine is an amino acid produced from the splitting off of urea from arginine. L-Ornithine allows for the disposal of excess nitrogen and acts as a precursor of citrulline and arginine. |
| PubChem ID: | 6262 |
| CasNo: | 70-26-8 |
| Repositioning for NAFLD: | Yes |
| SMILES: | NCCC[C@H](N)C(O)=O |
| Structure: |
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| InChiKey: | AHLPHDHHMVZTML-BYPYZUCNSA-N |
| Molecular Weight: | 132.161 |
| DrugBank Targets: | Ornithine aminotransferase, mitochondrial; Ornithine carbamoyltransferase, mitochondrial; Arginase-1; Ornithine decarboxylase antizyme 1; High affinity cationic amino acid transporter 1; Low affinity cationic amino acid transporter 2; Mitochondrial ornithine transporter 2; Arginase-2, mitochondrial; Mitochondrial ornithine transporter 1; Glycine amidinotransferase, mitochondrial |
| DrugBank MoA: | L-Ornithine is metabolised to L-arginine. L-arginine stimulates the pituitary release of growth hormone. Burns or other injuries affect the state of L-arginine in tissues throughout the body. As De novo synthesis of L-arginine during these conditions is usually not sufficient for normal immune function, nor for normal protein synthesis, L-ornithine may have immunomodulatory and wound-healing activities under these conditions (by virtue of its metabolism to L-arginine). |
| DrugBank Pharmacology: | A non-essential and nonprotein amino acid, ornithine is critical for the production of the body's proteins, enzymes and muscle tissue. Ornithine plays a central role in the urea cycle and is important for the disposal of excess nitrogen (ammonia). Ornithine is the starting point for the synthesis of many polyamines such as putrescine and spermine. Ornithine supplements are claimed to enhance the release of growth hormone and to burn excess body fat. Ornithine is necessary for proper immune function and good liver function. |
| DrugBank Indication: | Used for nutritional supplementation, also for treating dietary shortage or imbalance. It has been claimed that ornithine improves athletic performance, has anabolic effects, has wound-healing effects, and is immuno-enhancing. |
| Targets: | |
| Therapeutic Category: | |
| Clinical Trial Progress: | |
| Latest Progress: |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L4427 | NCT02497313 | COMPLETED | NO | 2015-07 | 2017-05-03 | Details | |
| L4429 | NCT01495013 | PHASE3 | COMPLETED | NO | 2011-12 | 2016-11-21 | Details |
| L6387 | NCT02719756 | PHASE4 | UNKNOWN | NO | 2016-04 | 2016-03-25 | Details |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
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| Article ID | PMID | Source | Title |
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