Investigational Drug Details
| Drug ID: | D161 |
| Drug Name: | Atropine |
| Synonyms: | |
| Type: | small molecule |
| DrugBank ID: | DB00572 |
| DrugBank Description: | An alkaloid, originally from Atropa belladonna, but found in other plants, mainly solanaceae. |
| PubChem ID: | 174174 |
| CasNo: | 51-55-8 |
| Repositioning for NAFLD: | Yes |
| SMILES: | CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(CO)C1=CC=CC=C1 |
| Structure: |
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| InChiKey: | RKUNBYITZUJHSG-SPUOUPEWSA-N |
| Molecular Weight: | 289.3694 |
| DrugBank Targets: | Muscarinic acetylcholine receptor M1; Muscarinic acetylcholine receptor M2; Muscarinic acetylcholine receptor M3; Muscarinic acetylcholine receptor M4; Muscarinic acetylcholine receptor M5; Glycine receptor subunit alpha-1; Neuronal acetylcholine receptor subunit alpha-4; Neuronal acetylcholine receptor subunit beta-2 |
| DrugBank MoA: | Atropine binds to and inhibit muscarinic acetylcholine receptors, producing a wide range of anticholinergic effects. |
| DrugBank Pharmacology: | Atropine, a naturally occurring belladonna alkaloid, is a racemic mixture of equal parts of d- and l-hyoscyamine, whose activity is due almost entirely to the levo isomer of the drug. Atropine is commonly classified as an anticholinergic or antiparasympathetic (parasympatholytic) drug. More precisely, however, it is termed an antimuscarinic agent since it antagonizes the muscarine-like actions of acetylcholine and other choline esters. Adequate doses of atropine abolish various types of reflex vagal cardiac slowing or asystole. The drug also prevents or abolishes bradycardia or asystole produced by injection of choline esters, anticholinesterase agents or other parasympathomimetic drugs, and cardiac arrest produced by stimulation of the vagus. Atropine may also lessen the degree of partial heart block when vagal activity is an etiologic factor. Atropine in clinical doses counteracts the peripheral dilatation and abrupt decrease in blood pressure produced by choline esters. However, when given by itself, atropine does not exert a striking or uniform effect on blood vessels or blood pressure. |
| DrugBank Indication: | For the treatment of poisoning by susceptible organophosphorous nerve agents having anti-cholinesterase activity (cholinesterase inhibitors) as well as organophosphorous or carbamate insecticides. |
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