Investigational Drug Details
| Drug ID: | D175 |
| Drug Name: | Fluphenazine |
| Synonyms: | |
| Type: | small molecule |
| DrugBank ID: | DB00623 |
| DrugBank Description: | A phenothiazine used in the treatment of psychoses. Its properties and uses are generally similar to those of chlorpromazine. |
| PubChem ID: | 3372 |
| CasNo: | 69-23-8 |
| Repositioning for NAFLD: | Yes |
| SMILES: | OCCN1CCN(CCCN2C3=CC=CC=C3SC3=C2C=C(C=C3)C(F)(F)F)CC1 |
| Structure: |
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| InChiKey: | PLDUPXSUYLZYBN-UHFFFAOYSA-N |
| Molecular Weight: | 437.522 |
| DrugBank Targets: | Dopamine D2 receptor; Dopamine D1 receptor; Calmodulin; Androgen receptor; 5-hydroxytryptamine receptor 2A; 5-hydroxytryptamine receptor 2C |
| DrugBank MoA: | Fluphenazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis. |
| DrugBank Pharmacology: | Fluphenazine is a trifluoro-methyl phenothiazine derivative intended for the management of schizophrenia and other psychotic disorders. Fluphenazine has not been shown effective in the management of behaviorial complications in patients with mental retardation. |
| DrugBank Indication: | For management of manifestations of psychotic disorders. |
| Targets: | |
| Therapeutic Category: | |
| Clinical Trial Progress: | |
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