Investigational Drug Details
| Drug ID: | D235 |
| Drug Name: | Fosfomycin |
| Synonyms: | |
| Type: | small molecule |
| DrugBank ID: | DB00828 |
| DrugBank Description: | An antibiotic produced by Streptomyces fradiae. |
| PubChem ID: | 446987 |
| CasNo: | 23155-02-4 |
| Repositioning for NAFLD: | Yes |
| SMILES: | C[C@@H]1O[C@@H]1P(O)(O)=O |
| Structure: |
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| InChiKey: | YMDXZJFXQJVXBF-STHAYSLISA-N |
| Molecular Weight: | 138.059 |
| DrugBank Targets: | UDP-N-acetylglucosamine 1-carboxyvinyltransferase |
| DrugBank MoA: | Fosfomycin is a phosphoenolpyruvate analogue produced by Streptomyces that irreversibly inhibits enolpyruvate transferase (MurA), which prevents the formation of N-acetylmuramic acid, an essential element of the peptidoglycan cell wall. |
| DrugBank Pharmacology: | Fosfomycin is a broad spectrum antibiotic that concentrates in kidney and bladder and is used to treat uncomplicated urinary tract infections. Fosfomycin also reduces nephrotoxicity and ototoxicity of platinum-containing anti-tumor agents. |
| DrugBank Indication: | For the treatment of uncomplicated urinary tract infections (acute cystitis) in women due to susceptible strains of <i>Escherichia coli</i> and <i>Enterococcus faecalis</i>. |
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