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Investigational Drug Details

Drug ID: D240
Drug Name: Dobutamine
Synonyms:
Type: small molecule
DrugBank ID: DB00841
DrugBank Description: A beta-1 agonist catecholamine that has cardiac stimulant action without evoking vasoconstriction or tachycardia. It is proposed as a cardiotonic after myocardial infarction or open heart surgery.
PubChem ID: 36811
CasNo: 34368-04-2
Repositioning for NAFLD: Yes
SMILES: CC(CCC1=CC=C(O)C=C1)NCCC1=CC(O)=C(O)C=C1
Structure:
InChiKey: JRWZLRBJNMZMFE-UHFFFAOYSA-N
Molecular Weight: 301.3801
DrugBank Targets: Alpha-1 adrenergic receptors; Beta-1 adrenergic receptor; Beta-2 adrenergic receptor; Estrogen receptor alpha
DrugBank MoA: Dobutamine directly stimulates beta-1 receptors of the heart to increase myocardial contractility and stroke volume, resulting in increased cardiac output.
DrugBank Pharmacology: Dobutamine is a direct-acting inotropic agent whose primary activity results from stimulation of the beta-adrenoceptors of the heart while producing comparatively mild chronotropic, hypertensive, arrhythmogenic, and vasodilative effects. Dobutamine acts primarily on beta-1 adrenergic receptors, with negligible effects on beta-2 or alpha receptors. It does not cause the release of endogenous norepinephrine, as does dopamine.
DrugBank Indication: Indicated when parenteral therapy is necessary for inotropic support in the short-term treatment of patients with cardiac decompensation due to depressed contractility resulting either from organic heart disease or from cardiac surgical procedures.
Targets:
Therapeutic Category:
Clinical Trial Progress:
Latest Progress: